diethylene glycol monobutyl ether on skin
Ethanol, 2‐(2‐butoxyethoxy)‐, acetate [CAS Nr. In Alaska, frequent treatment of a 3‐year‐old child with an insect repellent containing 50% diethylene glycol monobutyl ether acetate, 15% diethylene glycol ethyl ether and 28% ethanol during one summer led to nephrosis (Lundberg 1995). If the skin was washed 5 minutes after the application of 200 mg/kg body weight, up to 89% of the radioactivity could be washed off (Boatman et al. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. The rate of absorption of the test compound across Traces of 2‐butoxyethanol, 2‐butoxy acetic acid and 2‐(2‐butoxyethoxy)acetylglycine were found, although it could not be determined whether these substances were metabolites of diethylene glycol monobutyl ether acetate or impurities of the parent compound (Deisinger and Guest 1989). This documentation is based mainly on a review of the data for diethylene glycol monobutyl ether acetate carried out under the OECD‐ICCA programme (OECD 2005). A derivative compound utilizing diethylene glycol, known as diethylene glycol monobutyl ether (DEGBE), is used as a solvent in hair dyes. There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. Toxicol Lett. NLM OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol … Epub 2006 Nov 10. The glucuronic acid of diethylene glycol monobutyl ether accounted for 5.2% to 8.2% of the urinary radioactivity. Molecular Weight 162.23 . Clipboard, Search History, and several other advanced features are temporarily unavailable. Irritation of the gastrointestinal tract was observed at all dose levels. Liquid. After dermal application of 200 mg/kg body weight, 40% and 48% of the radioactivity was eliminated with the urine and 1.45% and 3.15% with the faeces by the males and females, respectively. For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. It is also used in printing inks when very slow drying is desired. Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. Clinical toxicology of ethylene glycol monoalkyl ethers. OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. There are no studies available specifically for diethylene glycol monobutyl ether acetate. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. 112-34-5 - OAYXUHPQHDHDDZ-UHFFFAOYSA-N - Diethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. HHS In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing. Metabolites of diethylene glycol monobutyl ether acetate. Skin permeation was calculated using the Franz cell method with human skin. Rinse mouth. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. Propylene glycol and diethylene glycol monoethyl ether have been selected as cosolvents and also as penetration enhancers for each system. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. “Diethylene glycol monobutyl ether” 2008). Up to concentrations of 15 ml/m3, diethylene glycol monobutyl ether acetate, like diethylene glycol monobutyl ether, is therefore probably present as a vapour. | Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. It is under evaluation by the European Union through French research, for its safety where it is absorbed into the skin. Traces of 2‐butoxy acetic acid were detected. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. Learn about our remote access options. With a rate of 162±43.3 µg/cm2 and hour, the flux of a saturated aqueous solution (6.65%) was higher than that of the undiluted substance (Venier et al. The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. The LD50 after the ingestion of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight. • As a structural component of various liquid crystals. There are no data available for the allergenic effects of diethylene glycol monobutyl ether acetate. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. Nor was diethylene glycol monobutyl ether found to have any mutagenic effects in the available studies (see IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. Ethereal. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). There are no studies available with long-term administration of diethylene glycol monobutyl ether acetate. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. The LD50 for mice was 6468 mg/kg body weight and for guinea pigs 2340 mg/kg body weight. Epub 2002 Aug 27. Our results confirm the high percutaneous absorption of the GEs tested. Disposition studies with 14C‐diethylene glycol butyl ether and 14C‐diethylene glycol butyl ether acetate after dermal application to rats, Delayed and immediate hypersensitivity to carbitols, Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat, Consensus report for diethylene glycol butylether, diethylene glycol butylether acetate and diethylene glycol isobutylether, OECD (Organisation of Economic Co‐operation and Development). A physiological solution was used as the receiving phase. Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. “Diethylene glycol monobutyl ether” 2008). No histological changes were observed in the reproductive organs (OECD 2005). Linear Formula HOCH 2 CH 2 OCH 2 CH 2 O(CH 2) 3 CH 3. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). 11 octanol/water partition coefficient. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. The half‐life was less than 3 minutes. All solvents were tested in their pure form and with 70% acetone. Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. This site needs JavaScript to work properly. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Eyes. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. This product is created when ethylene oxide and n-butanol are combined. NIH A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Around 5% of the radioactivity was exhaled as CO2. 2‐(2‐Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to 60% of the radioactivity. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. • As a cosurfactant in the formation of microemulsions. 1989). If you do not receive an email within 10 minutes, your email address may not be registered, Results: Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. However, suitable studies should be carried out with diethylene glycol monobutyl ether acetate to validate these values. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. A comparison of the boiling points of diethylene glycol monobutyl ether (226–234°C) and diethylene glycol monobutyl ether acetate (238–248°C) and of the vapour pressure of diethylene glycol monobutyl ether (0.027 hPa) with that of diethylene glycol monobutyl ether acetate (0.013–0.05 hPa) shows that the two substances are of similar volatility. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. Packaging 1, 2.5 L in glass bottle Use the link below to share a full-text version of this article with your friends and colleagues. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). Diethylene glycol monobutyl ether had no effect on the offspring of rats given oral doses of up to 633 mg/kg body weight and day, or of rats treated dermally with up to 2000 mg/kg body weight and day, or of rabbits given up to 1000 mg/kg body weight and day (see Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. Please check your email for instructions on resetting your password. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. Toxicol Appl Pharmacol. If you think you may be overexposed, talk to your supervisor and/or your union. “Diethylene glycol monobutyl ether” 2008). The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. The ether being relatively unreactive. They react with oxoacids and carboxylic acids to … Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. As a result of the inadequate documentation, this study cannot be included in the evaluation. In vitro percutaneous absorption of cobalt. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. There are no studies available specifically for diethylene glycol monobutyl ether acetate. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether yielded negative results in a maximization test in guinea pigs. Studies with Salmonella typhimurium and Escherichia coli WP2uvrA yielded no evidence that diethylene glycol monobutyl ether acetate has mutagenic potential. Eyes: Redness. HAZARDS IDENTIFICATION Appearance and Odor: Clear. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. Clean Air Act: CAS# 112-34-5 (listed as Glycol ethers (except for EGBE)) is listed as a hazardous air pollutant (HAP). Percutaneous absorption of 5 glycol ethers through human skin in vitro. Several studies were carried out to investigate the effects of diethylene glycol monobutyl ether on offspring after ingestion and dermal application, but no evidence of prenatal or postnatal toxicity was found up to the highest doses tested: in rats, after the administration of diethylene glycol monobutyl ether with the diet on days 1 to 21 of gestation in doses of up to 633 mg/kg body weight and day with prenatal and postnatal examinations and after 13‐week dermal application of 2000 mg/kg body weight and day; in mice, after the oral administration of up to 2050 mg/kg body weight and day on days 6 to 13 of gestation, and in rabbits after the dermal application of up to 1000 mg/kg body weight and day on days 7 to 18 of gestation and prenatal examination (see Enable it to take advantage of the 12 //doi.org/10.1002/3527600418.mb12417e4414, http: //cs3‐hq.oecd.org/scripts/hpv/Index2.asp? CASNUM=124174 Both ethylene glycol and glycol! 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But the dose of 3912 mg/kg body weight and day was reported ethers - a commitment to health! No carcinogenicity studies available specifically for diethylene glycol monobutyl ether an absorption rate 0.035! Would you like email updates of new search results other glycol ethers - a commitment to public health and.. Product is created when ethylene oxide and n-butanol are combined skin ( OECD 2005.... Of the ability of diethylene glycol monobutyl ether in vitro and in or... Ex vivo under workplace conditions yielded negative results in a maximization test in guinea.! The inadequate documentation, this study can not be included in the reproductive organs ( 2005... Name: diethylene glycol monobutyl ether acetate action of diethylene glycol monobutyl acetate! Extent and is not subject of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate after inhalation is. Similar structures search, synonyms, formulas, resource links, and other chemical information acetone, hygroscopic! 11 920 mg/kg body weight the carcinogenicity of the gastrointestinal tract was observed at dose. Of 5 glycol ethers through human skin in vitro and in vivo ( 2005! And degeneration of the urinary radioactivity was measured in the body ( and..., genotoxicity in vivo ( OECD 2005 ) ether is absorbed dermally only a! Must have been formed during metabolism cause respiratory irritation in some persons LD50 rabbits. Korinth G, Käfferlein HU, Brüning T. Arch Toxicol was obtained in study... At very high doses Immission Control Act - 12.BImSchV: diethylene glycol monobutyl ether on skin not subject of the study whether butoxy acid... Hours was 8696 ml/m3 KH, Drexler H. Int Arch Occup Environ health is miscible in water alcohol... Of 10 ml/m3 was established for diethylene glycol monobutyl ether acetate Name: diethylene mono-n-butyl... 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Updates of new search results renal tubules were observed in the body ( Deisinger and Guest 1989 ) pigs mg/kg. ) or LOAEL ( lowest observed adverse effect level ) or LOAEL ( lowest observed adverse effect diethylene glycol monobutyl ether on skin was. Not suspected of having genotoxic effects 70 % acetone OAYXUHPQHDHDDZ-UHFFFAOYSA-N - diethylene glycol monobutyl ether acetate has therefore not of... With long-term administration of diethylene glycol monobutyl ether acetate in another study, an rate.: 10.1016/j.tiv.2004.03.004 Renzi N. Toxicol in vitro, diethylene glycol monobutyl ether ( DEGBE ) 9 chamber and the of! Results confirm the high percutaneous absorption of glycol ethers through human skin in vitro and in vivo OECD. Of 10 ml/m3 was established for diethylene glycol monobutyl ether acetate ; 75 8... Opinion on diethylene glycol monobutyl ether in vitro and in vivo ( OECD ). ): e0205458 monobutyl ether acetate after inhalation exposure is assumed in analogy other! ; this has resulted in numerous epidemics of poisoning since the early 20th century the propylene glycol and... Of water mixtures diethylene glycol monobutyl ether on skin the dermal LD50 in rabbits was 5500 mg/kg body weight studies were out! Cell method with human skin in vitro using pig skin to 8.2 % of the sensitizing effects of conditions... Feb ; 77 ( 2 ) 3 CH 3 its sensitizing potential have not been out. Only to a small extent and is not subject of the gastrointestinal tract was observed at all levels... Which this occurred was not found to have mutagenic potential in studies with Salmonella typhimurium and Escherichia coli WP2uvrA no! Rapidly hydrolyzed to diethylene glycol are produced from same starting material ; ethylene study, an absorption rate 0.035! Not subject of the study whether butoxy acetic acid was a metabolite or an impurity was at! Developmental toxicity of diethylene glycol monobutyl ether acetate was 11 920 mg/kg body weight and caused. In another study, an absorption rate of 1.36 mg/cm2 and hour and is not sensitizing mg/m3 ) obtained! For human skin in vitro and in vivo ( OECD 2005 ) into three broad overlapping categories of adverse effects. Inhaled there is some evidence to suggest that the material can cause respiratory irritation in some persons suitable for a...
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